Article
Multiple regions of alpha-synuclein are associated with Parkinson's disease.
Annals of neurology - 1 Apr 2005
Mueller Jakob C, Fuchs Julia, Hofer Anne, Zimprich Alexander, Lichtner Peter, Illig Thomas, Berg Daniela, Wüllner Ullrich, Meitinger Thomas, Gasser Thomas
Abstract excerpt
alpha-Synuclein is considered to play an important role in the pathogenesis of both the rare familial and the common sporadic forms of Parkinson's disease. Previous reports primarily have tested the association of alpha-synuclein promoter polymorphisms with idiopathic Parkinson's disease, but results are controversial. We first characterized the linkage disequilibrium structure of the alpha-synuclein gene region...
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