Article
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
Science (New York, N.Y.) - 27 Jun 1997
Polymeropoulos M H, Lavedan C, Leroy E, Ide S E, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos E S, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson W G, Lazzarini A M, Duvoisin R C, Di Iorio G, Golbe L I, Nussbaum R L
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern of familial aggregation has been documented for the disorder, and it was recently reported that a PD susceptibility gene in a large Italian kindred is located on the lon...
Topics
- Age of Onset
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Female
- Genes, Dominant
- Genetic Markers
- Greece
- Humans
- Italy
- Male
- Molecular Sequence Data