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Article

Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2008

Westerlund Marie, Belin Andrea Carmine, Anvret Anna, Håkansson Anna, Nissbrandt Hans, Lind Charlotta, Sydow Olof, Olson Lars, Galter Dagmar

Abstract excerpt

Alterations of brain and plasma alpha-synuclein levels and SNCA gene variability have been implicated in the pathogenesis of Parkinson's disease (PD). We therefore measured alpha-synuclein protein levels in postmortem PD and control cerebellum tissue using Western blot and investigated whether the levels correlated to SNCA genotype. We found markedly decreased alpha-synuclein levels in PD patients (n=16) compared...

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Identifiers

PMID: 18606870
DOI: 10.1096/fj.08-110148

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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