Article
α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.
Annals of neurology - 1 Jun 2016
Guella Ilaria, Evans Daniel M, Szu-Tu Chelsea, Nosova Ekaterina, Bortnick Stephanie F, Goldman Jennifer G, Dalrymple-Alford John C, Geurtsen Gert J, Litvan Irene, Ross Owen A, Middleton Lefkos T, Parkkinen Laura, Farrer Matthew J
Abstract excerpt
OBJECTIVE: The relationship between Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB) has long been debated. Although PD is primarily considered a motor disorder, cognitive impairment is often present at diagnosis, and only ∼20% of patients remain cognitively intact in the long term. Alpha-synuclein (SNCA) was first implicated in the pathogenesis of the disease when point...
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