Article
Identification of a risk haplotype of the alpha-synuclein gene in Japanese with sporadic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2006
Kobayashi Hideaki, Ujike Hiroshi, Hasegawa Junko, Yamamoto Mitsutoshi, Kanzaki Akihiro, Sora Ichiro
Abstract excerpt
alpha-Synuclein is one of the main components of Lewy bodies, a pathological marker of Parkinson's disease (PD). Certain missense mutations of the alpha-synuclein gene cause familial PD, but the role of the gene in sporadic PD is still controversial. We scrutinized polymorphisms of the alpha-synuclein gene in a Japanese population and investigated their associations with sporadic cases of PD. The 5' flanking...
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