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Parkinson's disease and α‐synuclein expression

1 Sept 2011

Abstract excerpt

Genetic studies of Parkinson's disease over the last decade or more have revolutionized our understanding of this condition. α-Synuclein was the first gene to be linked to Parkinson's disease, and is arguably the most important: the protein is the principal constituent of Lewy bodies, and variation at its locus is the major genetic risk factor for sporadic disease. Intriguingly, duplications and triplications of...

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PMID: 21887711
DOI: 10.1002/mds.23948

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