Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.

doi:10.1006/exnr.1998.6868

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Article

Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.

Experimental neurology - 1 Sept 1998

Higuchi S, Arai H, Matsushita S, Matsui T, Kimpara T, Takeda A, Shirakura K

Abstract excerpt

Recently, alpha-synuclein attracted attention when Polymeropoulos and colleagues identified a missense mutation of this gene (Science 276:2045-2047, 1997), which is responsible for a form of early-onset familial Parkinson's disease (PD). Immunohistochemically, alpha-synuclein is localized in Lewy...

Topics

Aged
Alzheimer Disease
DNA
Dementia
Genotype
Humans
Lewy Bodies
Middle Aged
Mutation
Nerve Tissue Proteins
Parkinson Disease
Phosphoproteins
Synucleins
alpha-Synuclein

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