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Article

Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease.

Human molecular genetics - 1 Apr 2006

Mizuta Ikuko, Satake Wataru, Nakabayashi Yuko, Ito Chiyomi, Suzuki Satoko, Momose Yoshio, Nagai Yoshitaka, Oka Akira, Inoko Hidetoshi, Fukae Jiro, Saito Yuko, Sawabe Motoji, Murayama Shigeo, Yamamoto Mitsutoshi, Hattori Nobutaka, Murata Miho, Toda Tatsushi

Abstract excerpt

Parkinson's disease (PD), one of the most common human neurodegenerative diseases, is characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. PD is a complex disorder with multiple genetic and environmental factors influencing disease risk. To identify susceptible genes for sporadic PD, we performed case-control association studies of 268 single nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 16500997
DOI: 10.1093/hmg/ddl030

Genes

SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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