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Article

Tbx2 Is Overexpressed and Plays an Important Role in Maintaining Proliferation and Suppression of Senescence in Melanomas

15 Mar 2005

Abstract excerpt

The INK4a and ARF genes found at the CDKN2A locus are key effectors of cellular senescence that is believed to act as a powerful anticancer mechanism. Accordingly, mutations in these genes are present in a wide variety of spontaneous human cancers and CDKN2A germ line mutations are found in familial melanoma. The TBX2 gene encoding a key developmental transcription factor is amplified in pancreatic cancer cell...

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PMID: 15781639
DOI: 10.1158/0008-5472.can-04-3045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tbx2 Is Overexpressed and Plays an Important Role in Maintaining Proliferation and Suppression of Senescence in MelanomasPMID 15781639Read ↗

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p16INK4a-induced senescence is disabled by melanoma-associated mutations.Semantic proximity Read ↗

CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent mannerSemantic proximity Read ↗

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TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cellsSemantic proximity Read ↗

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