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TBX3 and its splice variant TBX3 + exon 2a are functionally similar

28 Apr 2008

Abstract excerpt

Tbx3, a member of the conserved family of T-box developmental transcription factors, is a transcriptional repressor required during cardiogenesis for the formation and specification of the sinoatrial node, the pacemaker of the heart. Both the TBX3 and the highly related TBX2 genes are also associated with several cancers, most likely as a consequence of their powerful anti-senescence properties mediated via...

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PMID: 18444963
DOI: 10.1111/j.1755-148x.2008.00461.x

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