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Article

HdmX overexpression inhibits oncogene induced cellular senescence.

Cell cycle (Georgetown, Tex.) - 15 Aug 2010

Miller Kelly R, Kelley Kevin, Tuttle Rebecca, Berberich Steven J

Abstract excerpt

Cellular senescence is an irreversible state of terminal growth arrest that requires functional p53. Acting to block tumor formation, induction of senescence has also been demonstrated to contribute to tumor clearance via the immune system following p53 reactivation. The Hdm2-antagonist, Nutlin-3a, has been shown to reactivate p53 and induce a quiescent state in various cancer cell lines, similar to the G(1)...

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Identifiers

PMID: 20724842
DOI: 10.4161/cc.9.16.12779
PMCID: PMC3041169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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