Article
Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation.
Oncogene - 30 May 2002
Carlson Hanqian, Ota Sara, Song Youngsup, Chen Yanwen, Hurlin Peter J
Abstract excerpt
Tbx3 is a member of the T-box family of transcription factors. Mutations in Tbx3 cause ulnar-mammary syndrome, an autosomal dominant disorder characterized by upper limb defects, apocrine-gland defects including mammary hypoplasia, and tooth, hair and genital defects. In cell culture, Tbx3 and its close relative Tbx2 are capable of immortalizing mouse embryo fibroblasts. We show that expression of Tbx3 together...
Topics
- 3T3 Cells
- Animals
- Apoptosis
- Blotting, Northern
- Blotting, Western
- Cell Differentiation
- Cell Separation
- Cell Transformation, Neoplastic
- Cells, Cultured
- Down-Regulation
- Fibroblasts