Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

doi:10.1016/s1097-2765(00)80182-3

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Article

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

Molecular cell - 1 Jul 1999

Lee H, Trainer A H, Friedman L S, Thistlethwaite F C, Evans M J, Ponder B A, Venkitaraman A R

Abstract excerpt

The murine Brca2 gene encodes a nuclear protein implicated in DNA repair. Brca2 behaves as a tumor suppressor, but paradoxically, its truncation causes proliferative arrest and spontaneous chromosomal damage. Here, we report that inactivation of cell cycle checkpoints responsive to mitotic spindle disruption, by mutant forms of p53 or Bub1, relieves growth arrest and initiates neoplastic transformation in primary...

Topics

Animals
BRCA2 Protein
Breast Neoplasms
Cell Transformation, Neoplastic
Cells, Cultured
Chromosome Aberrations
DNA Damage
Genes, Neoplasm
Genes, Tumor Suppressor
Humans
Interphase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma

Mice

Mitosis

Mutation

Neoplasm Proteins

Protein Kinases

Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 10445022
DOI: 10.1016/s1097-2765(00)80182-3

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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