TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

doi:10.1074/jbc.M110492200

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Article

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.

The Journal of biological chemistry - 22 Feb 2002

Brummelkamp Thijn R, Kortlever Roderik M, Lingbeek Merel, Trettel Flavia, MacDonald Marcy E, van Lohuizen Maarten, Bernards René

Abstract excerpt

Prolonged culturing of rodent cells in vitro activates p19(ARF) (named p14(ARF) in man), resulting in a p53-dependent proliferation arrest known as senescence. The p19(ARF)-Mdm2-p53 pathway also serves to protect primary cells against oncogenic transformation. We have used a genetic screen in mou...

Topics

Aging
Animals
Bone Diseases
Breast Diseases
COS Cells
Cell Line
Cells, Cultured
Chlorocebus aethiops
Corpus Striatum
Cyclin-Dependent Kinase Inhibitor p16
Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Gene Expression Regulation

Gene Library

Genes, p16

Genes, p53

Humans

Mice

Source

Open in PubMed

Identifiers

PMID: 11748239
DOI: 10.1074/jbc.M110492200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-11748239-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.PMID 11748239Read ↗

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Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation.Semantic proximity Read ↗

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