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Article

TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells

13 Jan 2014

Abstract excerpt

Rhabdomyosarcomas (RMSs) are the most frequent soft tissue sarcomas in children that share many features of developing skeletal muscle. We have discovered that a T-box family member, TBX2, is highly upregulated in tumor cells of both major RMS subtypes. TBX2 is a repressor that is often overexpressed in cancer cells and is thought to function in bypassing cell growth control, including repression of p14 and p21....

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PMID: 24470334
DOI: 10.1002/ijc.28721

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TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cellsPMID 24470334Read ↗

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