Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.

doi:10.1093/nar/gki303

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Article

Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability.

Nucleic acids research - 1 Jan 2005

Oda Shinya, Maehara Yoshihiko, Ikeda Yoichi, Oki Eiji, Egashira Akinori, Okamura Yoshikazu, Takahashi Ikuo, Kakeji Yoshihiro, Sumiyoshi Yasushi, Miyashita Kaname, Yamada Yu, Zhao Yan, Hattori Hiroyoshi, Taguchi Ken-ichi, Ikeuchi Tatsuro, Tsuzuki Teruhisa, Sekiguchi Mutsuo, Karran Peter, Yoshida Mitsuaki A

Abstract excerpt

Microsatellite instability (MSI) is associated with defective DNA mismatch repair in various human malignancies. Using a unique fluorescent technique, we have observed two distinct modes of dinucleotide microsatellite alterations in human colorectal cancer. Type A alterations are defined as length changes of < or =6 bp. Type B changes are more drastic and involve modifications of > or =8 bp. We show here that...

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PMID: 15778432
DOI: 10.1093/nar/gki303
PMCID: PMC1067522

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