Article
Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?
Mutation research - 1 Jan 2000
Hile Suzanne E, Shabashev Samion, Eckert Kristin A
Abstract excerpt
Microsatellite DNA sequences display allele length alterations or microsatellite instability (MSI) in tumor tissues, and MSI is used diagnostically for tumor detection and classification. We discuss the known types of tumor-specific MSI patterns and the relevant mechanisms underlying each pattern. Mutation rates of individual microsatellites vary greatly, and the intrinsic DNA features of motif size, sequence,...
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