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Article

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability.

Oncogene - 30 Aug 2007

Miquel C, Jacob S, Grandjouan S, Aimé A, Viguier J, Sabourin J-C, Sarasin A, Duval A, Praz F

Abstract excerpt

Accumulation of frameshift mutations at genes containing coding mononucleotide repeats is thought to be the major molecular mechanism by which mismatch repair-deficient cells accumulate functional alterations. These mutations resulting from microsatellite instability (MSI) can affect genes involv...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17384679
DOI: 10.1038/sj.onc.1210419

Genes

RAD50
ATR
MBD4
MRE11
MSH3
MSH6
POLD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17384679-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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