Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting microsatellite instability in colorectal cancer: one size does not fit all.

Genome medicine - 24 May 2017

Samstein Robert M, Chan Timothy A

Abstract excerpt

Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might have consequences for the potential use of immunotherapy in MSI-positive cancers.See related research by Sveen et...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms
Share to DNA Mismatch Repair
Share to Microsatellite Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 28539127
DOI: 10.1186/s13073-017-0438-9
PMCID: PMC5442871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting microsatellite instability in colorectal cancer: one size does not fit all.PMID 28539127Read ↗

Importance of microsatellite instability (MSI) in colorectal cancer: MSI as a diagnostic toolSemantic proximity Read ↗

Toward a Molecular Classification of Colorectal Cancer: The Role of Microsatellite Instability StatusSemantic proximity Read ↗

Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part I-Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications.Semantic proximity Read ↗

Microsatellite instability: A potential game-changer in colorectal cancer diagnosis and treatmentSemantic proximity Read ↗

Microsatellite Instability and Therapeutic Consequences in Colorectal CancerSemantic proximity Read ↗

Microsatellite instability in cancer: a novel landscape for diagnostic and therapeutic approach.Semantic proximity Read ↗

Microsatellite Instability: From the Implementation of the Detection to a Prognostic and Predictive Role in CancersSemantic proximity Read ↗

Microsatellite Instability and Mismatch Repair Subclonality in Human Cancers: Biologic Basis, Diagnostic Pitfalls, and Therapeutic Implications With a Focus on Colorectal CancerSemantic proximity Read ↗

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.Semantic proximity Read ↗

A molecular portrait of microsatellite instability across multiple cancers.Semantic proximity Read ↗

Immunotherapy and patients treated for cancer with microsatellite instability.Semantic proximity Read ↗

Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.