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DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

23 Dec 2009

Abstract excerpt

DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC), and is characterized by the loss of function of the MMR pathway. Failure to repair replication-associated errors due to a defective MMR system allows persistence of mismatch mutations all over the genome, but especially in regions of repetitive DNA known as microsatellites, giving rise to...

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PMID: 20102395
DOI: 10.1111/j.1365-2559.2009.03392.x

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