Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability.

doi:10.1016/j.suronc.2007.10.018

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Article

Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability.

Surgical oncology - 1 Dec 2007

Dionigi G, Bianchi V, Villa F, Rovera F, Boni L, Annoni M, Castano P, Dionigi R

Abstract excerpt

Microsatellite instability (MSI) is observed in approximately 13% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumourigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumours. MSI caused by deficient DNA mismatch-repair functions is a hallmark of cancers...

Topics

Adaptor Proteins, Signal Transducing
Colorectal Neoplasms
DNA Methylation
Genes, APC
Humans
Microsatellite Instability
MutL Protein Homolog 1
MutL Proteins
Mutation
Neoplasm Proteins
Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 18023569
DOI: 10.1016/j.suronc.2007.10.018

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