Article
Immortalization of conditionally transformed chicken cells: loss of normal p53 expression is an early step that is independent of cell transformation.
Genes & development - 1 May 1992
Ulrich E, Boehmelt G, Bird A, Beug H
Abstract excerpt
Clones of mortal chicken fibroblasts and erythroblasts transformed by temperature-sensitive v-src and v-erb B oncoproteins have been developed into immortal cell lines that retain the conditional transformed phenotype. The expressions of two tumor suppressor genes, the retinoblastoma (Rb) gene an...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cell Line
- Cell Transformation, Viral
- Chickens
- Gene Expression
- Genes, Retinoblastoma
- Genes, p53
- Molecular Sequence Data
- Mutation
- Oncogenes
- Polymerase Chain Reaction
- Temperature