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Article

A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.

Biochemical and biophysical research communications - 5 Feb 2000

Tsuji T, Miyazaki M, Sakaguchi M, Inoue Y, Namba M

Abstract excerpt

Normal human cells stop proliferation after a certain number of cell divisions. This phenomenon is called cellular aging. The fact that the senescence phenotype is dominant and the immortal one is recessive indicates that immortalization of human cells may be caused by loss of functions of certain genes in normal cells. Based on this evidence, several cDNA clones whose expression was down-regulated during the...

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Identifiers

PMID: 10652205
DOI: 10.1006/bbrc.1999.2067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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