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Article

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.

Molecular and cellular biology - 1 Mar 2006

Kortum Robert L, Johnson Heidi J, Costanzo Diane L, Volle Deanna J, Razidlo Gina L, Fusello Angela M, Shaw Andrey S, Lewis Robert E

Abstract excerpt

In primary mouse embryo fibroblasts (MEFs), oncogenic Ras induces growth arrest via Raf/MEK/extracellular signal-regulated kinase (ERK)-mediated activation of the p19ARF/p53 and INK4/Rb tumor suppressor pathways. Ablation of these same pathways causes spontaneous immortalization in MEFs, and oncogenic transformation by Ras requires ablation of one or both of these pathways. We show that Kinase Suppressor of Ras 1...

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Identifiers

PMID: 16507997
DOI: 10.1128/MCB.26.6.2202-2214.2006
PMCID: PMC1430273

Genes

KSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.PMID 16507997Read ↗

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