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Article

Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1.

Oncogene - 1 Jul 1993

Catling A D, Wyke J A, Frame M C

Abstract excerpt

Activation of rapidly reversible temperature-sensitive (ts) v-Src in quiescent chicken embryo fibroblasts (CEFs) results in both morphological transformation and exit from G0 to G1, resulting in mitosis. This phenomenon permits examination of cellular responses very soon after activating the oncoprotein, and we have used this to study changes in endogenous AP-1, and the regulation of its major components, in the...

Read the complete abstract on PubMed

Topics

Animals
Base Sequence
Cell Division
Cell Membrane
Chick Embryo
DNA
Fibroblasts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression

Genes, fos

Genes, jun

Molecular Sequence Data

Mutation

Oncogene Protein pp60(v-src)

Phosphorylation

Protein-Tyrosine Kinases

Proto-Oncogene Proteins c-jun

Transcription, Genetic

Source

Identifiers

PMID: 8510932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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