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Article

Conditional likelihood score functions for mixed models in linkage analysis.

Biostatistics (Oxford, England) - 1 Apr 2005

Hössjer Ola

Abstract excerpt

In this paper, we develop a general strategy for linkage analysis, applicable for arbitrary pedigree structures and genetic models with one major gene, polygenes and shared environmental effects. Extending work of Whittemore (1996), McPeek (1999) and Hossjer (2003d), the efficient score statistic is computed from a conditional likelihood of marker data given phenotypes. The resulting semiparametric linkage...

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PMID: 15772109
DOI: 10.1093/biostatistics/kxi012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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