Efficiency robust statistics for genetic linkage and association studies under genetic model uncertainty

Abstract excerpt

When testing genetic linkage and association, test statistics that follow a normal or Chi-square distributions are often used. These statistics are usually derived under a specific mode of inheritance (genetic model). Common genetic models include, but not limited to, the recessive, additive, multiplicative, and dominant models. For many diseases, their underlying genetic models are often unknown. Instead, a...

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