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Article

Testing genetic linkage with relative pairs and covariates by quasi-likelihood score statistics.

Human heredity - 1 Jan 2007

Schaid Daniel J, Sinnwell Jason P, Thibodeau Stephen N

Abstract excerpt

BACKGROUND/AIMS: Genetic linkage analysis of common diseases is complicated by the heterogeneity of genetic and environmental factors that increase disease risk, and possibly interactions among them. Most linkage methods that account for covariates are restricted to sib pairs, with the exception of the conditional logistic regression model [1] implemented in LODPAL in the S.A.G.E. software [2]. Although this...

Topics

Female
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Humans
Likelihood Functions
Male
Models, Genetic
Pedigree
Prostatic Neoplasms

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PMID: 17565225
DOI: 10.1159/000103751
PMCID: PMC2880728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17565225-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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