A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents.

doi:10.1002/gepi.20084

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Article

A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents.

Genetic epidemiology - 1 Sept 2005

Kistner Emily O, Weinberg Clarice R

Abstract excerpt

When studying either qualitative or quantitative traits, tests of association in the presence of linkage are necessary for fine-mapping. In a previous report, we suggested a polytomous logistic approach to testing linkage and association between a di-allelic marker and a quantitative trait locus, using genotyped triads, consisting of an individual whose quantitative trait has been measured and his or her two...

Topics

Alleles
Computer Simulation
Genotype
Humans
Linkage Disequilibrium
Logistic Models
Models, Genetic
Nuclear Family
Parents
Pedigree
Quantitative Trait Loci
Quantitative Trait, Heritable
Siblings

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Open in PubMed

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PMID: 16025442
DOI: 10.1002/gepi.20084

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