Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.

Abstract excerpt

There is a lot of confusion in the literature about the "differences" between "model-based" and "model-free" methods and about which approach is better suited for detection of the genes predisposing to complex multifactorial phenotypes. By starting from first principles, we demonstrate that the differences between the two approaches have more to do with study design than statistical analysis. When simple data...

Topics

• Case-Control Studies
• Chromosome Mapping
• Computer Simulation
• Female
• Genes, Dominant
• Genetic Diseases, Inborn
• Genetic Markers
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Likelihood Functions
• Linkage Disequilibrium