Article
High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells.
Molecular immunology - 1 Jul 2013
Kano Chie, Wang Ji-Yang
Abstract excerpt
Ig gene somatic hypermutation in the germinal center (GC) B cells occurs at C and G at roughly the same frequency. In contrast, there is a 2-fold increase of mutations at A relative to T on the non-transcribed strand of the V genes but it is unclear what triggers such strand bias. Using an efficient mutagenesis system that recapitulates characteristic features of Ig gene hypermutation in the GC B cells, we found...
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