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Article

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.

Science (New York, N.Y.) - 14 Jun 2002

Yoshikawa Kiyotsugu, Okazaki Il-Mi, Eto Tomonori, Kinoshita Kazuo, Muramatsu Masamichi, Nagaoka Hitoshi, Honjo Tasuku

Abstract excerpt

Activation-induced cytidine deaminase (AID), a putative RNA-editing enzyme, is indispensable for somatic hypermutation (SHM), class switch recombination, and gene conversion of immunoglobulin genes, which indicates a common molecular mechanism for these phenomena. Here we show that ectopic expression of AID alone can induce hypermutation in an artificial GFP substrate in NIH 3T3 murine fibroblast cells. The...

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Source

Identifiers

PMID: 12065838
DOI: 10.1126/science.1071556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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