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Article

Somatic hypermutation of the AID transgene in B and non-B cells

29 Aug 2002

Abstract excerpt

Somatic hypermutation (SHM) of the Ig genes is required for affinity maturation of the humoral response to foreign antigens. Activation-induced cytidine deaminase (AID), which is specifically expressed in germinal center centroblasts, is indispensable for this process. Expression of AID is sufficient to activate SHM in hybridomas, non-B cells, and Escherichia coli, suggesting that it initiates the mutational...

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Identifiers

PMID: 12202747
DOI: 10.1073/pnas.192442899

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