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Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma

28 Apr 2003

Abstract excerpt

The pathogenesis of AIDS-related non-Hodgkin lymphomas (AIDS-NHLs) is associated with chromosomal translocations that deregulate the expression of various oncogenes. Recently, a novel mechanism of genetic lesion, termed aberrant hypermutation, has been identified in diffuse large B-cell lymphoma (DLBCL) of immunocompetent hosts. In these tumors, the somatic hypermutation (SHM) process that normally targets...

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PMID: 12714522
DOI: 10.1182/blood-2002-11-3606

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