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Article

Attracting AID to targets of somatic hypermutation.

The Journal of experimental medicine - 15 Feb 2010

Tanaka Atsushi, Shen Hong Ming, Ratnam Sarayu, Kodgire Prashant, Storb Ursula

Abstract excerpt

The process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes requires activation-induced cytidine deaminase (AID). Although mistargeting of AID is detrimental to genome integrity, the mechanism and the cis-elements responsible for targeting of AID are largely unknown. We show that three CAGGTG cis-elements in the context of Ig enhancers are sufficient to target SHM to a nearby transcribed gene. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Share to Somatic Hypermutation, Immunoglobulin

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Source

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Identifiers

PMID: 20100870
DOI: 10.1084/jem.20090821
PMCID: PMC2822603

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attracting AID to targets of somatic hypermutation.PMID 20100870Read ↗

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.Semantic proximity Read ↗

Epigenetic targeting of activation-induced cytidine deaminaseSemantic proximity Read ↗

Why does somatic hypermutation by AID require transcription of its target genes?Semantic proximity Read ↗

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Semantic proximity Read ↗

The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Semantic proximity Read ↗

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.Semantic proximity Read ↗

Somatic hypermutation of the AID transgene in B and non-B cellsSemantic proximity Read ↗

Genome-wide somatic hypermutation.Semantic proximity Read ↗

The E Box Motif CAGGTG Enhances Somatic Hypermutation without Enhancing TranscriptionSemantic proximity Read ↗

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Semantic proximity Read ↗

Multiple Transcription Factor Binding Sites Predict AID Targeting in Non-Ig GenesSemantic proximity Read ↗

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.Semantic proximity Read ↗

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