Article
N-myristoyltransferase 1 is essential in early mouse development.
The Journal of biological chemistry - 13 May 2005
Yang Shao H, Shrivastav Anuraag, Kosinski Cynthia, Sharma Rajendra K, Chen Miao-Hsueh, Berthiaume Luc G, Peters Luanne L, Chuang Pao-Tien, Young Stephen G, Bergo Martin O
Abstract excerpt
N-Myristoyltransferase (NMT) transfers myristate to an amino-terminal glycine of many eukaryotic proteins. In yeast, worms, and flies, this enzyme is essential for viability of the organism. Humans and mice possess two distinct but structurally similar enzymes, NMT1 and NMT2. These two enzymes have similar peptide specificities, but no one has examined the functional importance of the enzymes in vivo. To address...
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