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Article

Regulatory subunit myristoylation antagonizes calcineurin phosphatase activation in yeast.

The Journal of biological chemistry - 16 Nov 2012

Connolly Sean, Kingsbury Tami

Abstract excerpt

The Ca(2+)/calmodulin-stimulated protein phosphatase calcineurin is a critical component of Ca(2+) signaling cascades in eukaryotic cells. Myristoylation of the regulatory subunit of calcineurin (CNB) is conserved from yeast to humans. Here, we show that CNB myristoylation antagonizes phosphatase activation in yeast. Disruption of CNB myristoylation by mutation of the myristoylated glycine triggered constitutive...

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Identifiers

PMID: 23027860
DOI: 10.1074/jbc.M112.366617
PMCID: PMC3501033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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