Article
Drosophila lysophospholipid acyltransferases are specifically required for germ cell development.
Molecular biology of the cell - 1 Dec 2009
Steinhauer Josefa, Gijón Miguel A, Riekhof Wayne R, Voelker Dennis R, Murphy Robert C, Treisman Jessica E
Abstract excerpt
Enzymes of the membrane-bound O-acyltransferase (MBOAT) family add fatty acyl chains to a diverse range of protein and lipid substrates. A chromosomal translocation disrupting human MBOAT1 results in a novel syndrome characterized by male sterility and brachydactyly. We have found that the Drosophila homologues of MBOAT1, Oysgedart (Oys), Nessy (Nes), and Farjavit (Frj), are lysophospholipid acyltransferases....
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