Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.

Mechanisms of development - 1 Jan 2000

Wang Sui, Zhang Jia, Zhao Aizhen, Hipkens Susan, Magnuson Mark A, Gu Guoqiang

Abstract excerpt

Myelin transcription factor 1 (Myt1) is one of the three vertebrate C2HC-type zinc finger transcription factors that include Myt1 (Nzf1), Myt1L (Png1), and Myt3 (Nzf3, St18). All three paralogs are widely expressed in developing neuronal cells. Yet their function for mammalian development has not been investigated directly. Here we report that only Myt1 is expressed in the embryonic pancreas, in both endocrine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Insulin Secretion

Share to Integrases

Share to Islets of Langerhans

Share to Organ Specificity

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 17928203
DOI: 10.1016/j.mod.2007.08.004
PMCID: PMC2141686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.PMID 17928203Read ↗

Metabolic Stress Levels Influence the Ability of Myelin Transcription Factors to Regulate β-Cell Identity and SurvivalSemantic proximity Read ↗

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMSemantic proximity Read ↗

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and functionSemantic proximity Read ↗

Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDMSemantic proximity Read ↗

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the PancreasSemantic proximity Read ↗

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.Semantic proximity Read ↗

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-CellsSemantic proximity Read ↗

NeuroD1 in the endocrine pancreas: Localization and dual function as an activator and repressorSemantic proximity Read ↗

Mind bomb 1 is required for pancreatic β-cell formation.Semantic proximity Read ↗

Nuclear inhibitor of protein phosphatase 1 (NIPP1) regulates CNS tau phosphorylation and myelination during developmentSemantic proximity Read ↗

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.Semantic proximity Read ↗

The what, where, when and how of Wnt/β-catenin signaling in pancreas developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.