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Article

Loss-of-function approach using mouse retinal explants showed pivotal roles of Nmnat2 in early and middle stages of retinal development.

Molecular biology of the cell - 1 Jan 2023

Kuribayashi Hiroshi, Katahira Miku, Aihara Makoto, Suzuki Yutaka, Watanabe Sumiko

Abstract excerpt

Nicotinamide mononucleotide adenylyltransferase (Nmnat) is a class of enzymes with three members (Nmnat1-3). Nmnat1 is in nucleus and associated with Leber congenital amaurosis, a form of early-onset retinal degeneration, while Nmnat2 is in cytoplasm and a well-characterized neuroprotective factor. The differences in their biological roles in the retina are unclear. We performed short hairpin RNA (shRNA)-based...

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Identifiers

PMID: 36322391
DOI: 10.1091/mbc.E22-03-0078
PMCID: PMC9816650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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