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Article

Deficiency in a glutamine-specific methyltransferase for release factor causes mouse embryonic lethality.

Molecular and cellular biology - 1 Sept 2010

Liu Peng, Nie Song, Li Bing, Yang Zhong-Qiang, Xu Zhi-Mei, Fei Jian, Lin Chyuansheng, Zeng Rong, Xu Guo-Liang

Abstract excerpt

Biological methylation is a fundamental enzymatic reaction for a variety of substrates in multiple cellular processes. Mammalian N6amt1 was thought to be a homologue of bacterial N(6)-adenine DNA methyltransferases, but its substrate specificity and physiological importance remain elusive. Here, we demonstrate that N6amt1 functions as a protein methyltransferase for the translation termination factor eRF1 in...

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Identifiers

PMID: 20606008
DOI: 10.1128/MCB.00218-10
PMCID: PMC2937546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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