Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional Ablation of Nonmuscle Myosin II-B Delineates Heart Defects in Adult Mice

9 Oct 2009

Abstract excerpt

RATIONALE: Germline ablation of the cytoskeletal protein nonmuscle myosin II (NMII)-B results in embryonic lethality, with defects in both the brain and heart. Tissue-specific ablation of NMII-B by a Cre recombinase strategy should prevent embryonic lethality and permit study of the function of NMII-B in adult hearts. OBJECTIVE: We sought to understand the function of NMII-B in adult mouse hearts and to see...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Arrhythmias and Treatments
Share to Cardiac electrophysiology and arrhythmias
Share to Cardiomyopathy and Myosin Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19815823
DOI: 10.1161/circresaha.109.200303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional Ablation of Nonmuscle Myosin II-B Delineates Heart Defects in Adult MicePMID 19815823Read ↗

Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice.Semantic proximity Read ↗

Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis.Semantic proximity Read ↗

The role of vertebrate nonmuscle Myosin II in development and human diseaseSemantic proximity Read ↗

Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes.Semantic proximity Read ↗

Growth and Muscle Defects in Mice Lacking Adult Myosin Heavy Chain GenesSemantic proximity Read ↗

The effects of conditional loss of myosin binding protein H-like on cardiac functionSemantic proximity Read ↗

Generation and characterization of a conditional deletion allele for Lmna in mice.Semantic proximity Read ↗

Nonmuscle myosin II isoform and domain specificity during early mouse development.Semantic proximity Read ↗

Deletion of cytoplasmic β/γ-actin in the mouse heart protects from disease by augmenting sarcolemma stabilitySemantic proximity Read ↗

Roles of Nebulin Family Members in the Heart.Semantic proximity Read ↗

Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice.Semantic proximity Read ↗

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.