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Article

c-Abl tyrosine kinase regulates cardiac growth and development.

Proceedings of the National Academy of Sciences of the United States of America - 19 Jan 2010

Qiu Zhaozhu, Cang Yong, Goff Stephen P

Abstract excerpt

The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. Here we show that homozygous Abl mutant embryos and newborns on the C57BL/6J background, but not on other backgrounds, display dramatically enlarged hearts and die perinatally. The heart defects can be largely rescued by...

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Identifiers

PMID: 20080568
DOI: 10.1073/pnas.0913131107
PMCID: PMC2824287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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