Article
A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development.
Molecular and cellular biology - 1 Aug 2009
Francis Sarah M, Bergsied Jacqueline, Isaac Christian E, Coschi Courtney H, Martens Alison L, Hojilla Carlo V, Chakrabarti Subrata, Dimattia Gabriel E, Khoka Rama, Wang Jean Y J, Dick Frederick A
Abstract excerpt
Transforming growth factor beta (TGF-beta) is a crucial mediator of breast development, and loss of TGF-beta-induced growth arrest is a hallmark of breast cancer. TGF-beta has been shown to inhibit cyclin-dependent kinase (CDK) activity, which leads to the accumulation of hypophosphorylated pRB. However, unlike other components of TGF-beta cytostatic signaling, pRB is thought to be dispensable for mammary...
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