Article
The NF-κB1 is a key regulator of acute but not chronic renal injury.
Cell death & disease - 15 Jun 2017
Fearn Amy, Situmorang Gerhard R, Fox Christopher, Oakley Fiona, Howarth Rachel, Wilson Caroline L, Kiosia Agklinta, Robson Michael G, Mann Derek A, Moles Anna, Sheerin Neil S
Abstract excerpt
The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inhibit transcription, acting as a brake to the recognised pro-inflammatory activity of other NF-κB...
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