Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy.

Mediators of inflammation - 1 Jan 2015

DeSantis David A, Ko Chih-Wei, Wang Lan, Lee Peter, Croniger Colleen M

Abstract excerpt

TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activation of the Nlrc4 inflammasome may lead to induced hepatocyte proliferation and prevent the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon Tetrachloride
Share to Hepatectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inflammasomes

Share to Interleukin-1beta

Share to Liver Regeneration

Share to Mice, Congenic

Share to Mice, Inbred A

Share to RAW 264.7 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 26635450
DOI: 10.1155/2015/909827
PMCID: PMC4655266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy.PMID 26635450Read ↗

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinomaSemantic proximity Read ↗

Interleukin 17-producing γδT cells promote hepatic regeneration in mice.Semantic proximity Read ↗

Toll-like receptor 5-mediated signaling enhances liver regeneration in miceSemantic proximity Read ↗

The Role of the NLRP3 Inflammasome in HCC Carcinogenesis and Treatment: Harnessing Innate ImmunitySemantic proximity Read ↗

Galectin-1 is essential for efficient liver regeneration following hepatectomy.Semantic proximity Read ↗

MAIT cells exacerbate liver fibrosis by downsizing the intrahepatic regulatory T cell compartmentSemantic proximity Read ↗

Selective activation of Toll-like receptor 7 in activated hepatic stellate cells may modulate their profibrogenic phenotype.Semantic proximity Read ↗

Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.Semantic proximity Read ↗

Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice.Semantic proximity Read ↗

Multiorgan chronic inflammatory hepatobiliary pancreatic murine model deficient in tumor necrosis factor receptors 1 and 2.Semantic proximity Read ↗

Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7Semantic proximity Read ↗

Loss of hepatocyte cell division leads to liver inflammation and fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.