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Article

M2-like Kupffer cells in fibrotic liver may protect against acute insult.

World journal of gastroenterology - 28 May 2017

Zheng Qing-Fen, Bai Li, Duan Zhong-Ping, Han Yuan-Ping, Zheng Su-Jun, Chen Yu, Li Jian-Sheng

Abstract excerpt

AIM: To investigate the mechanism of hepatoprotection conferred by liver fibrosis through evaluating the activation phenotype of kupffer cells. METHODS: Control and fibrotic mice were challenged with a lethal dose of D-GalN/lipopolysaccharide (LPS), and hepatic damage was assessed by histology, serum alanine transferase (ALT) levels, and hepatic expression of HMGB1, a potent pro-inflammatory mediator. The...

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Identifiers

PMID: 28611518
DOI: 10.3748/wjg.v23.i20.3655
PMCID: PMC5449422

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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