Article

Functional IKK/NF-κB Signaling in Pancreatic Stellate Cells is Essential to Prevent Autoimmune Pancreatitis

2021-09-16

Abstract excerpt

<title>Abstract</title> <p>Pancreatic stellate cells (PSCs) are resident cells in the exocrine pancreas which contribute to pancreatic fibrogenesis and inflammation. Studies on NF-κB in pancreatitis so far focused mainly on the parenchymal and myeloid compartments. Its function in PSCs during chronic pancreatitis has not been investigated. Here we show a protective immunomodulatory function of NF-κB in PSCs. Cond...

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Literature Corpus work: 79b5dfb3-6f48-576a-8d7d-4501d4f0e961
DOI: 10.21203/rs.3.rs-887736/v1

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