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Article

Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis.

The Journal of experimental medicine - 7 Mar 2005

Dequiedt Franck, Van Lint Johan, Lecomte Emily, Van Duppen Viktor, Seufferlein Thomas, Vandenheede Jackie R, Wattiez Ruddy, Kettmann Richard

Abstract excerpt

The molecular basis of thymocyte negative selection, a crucial mechanism in establishing central tolerance, is not yet resolved. Histone deacetylases (HDACs) have emerged as key transcriptional regulators in several major developmental programs. Recently, we showed that the class IIa member, HDAC7, regulates negative selection by repressing expression of Nur77, an orphan nuclear receptor involved in...

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Source

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Identifiers

PMID: 15738054
DOI: 10.1084/jem.20042034
PMCID: PMC2212830

Genes

HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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