Article

HDAC7 controls anti-viral and anti-tumor immunity by CD8 <sup>+</sup> T cells

2022-09-19

Abstract excerpt

Class II histone deacetylases (HDAC) orchestrate T cell-dependent immune responses via the epigenetic control of genes and via the post-translational modification of cytoplasmic and nuclear proteins. However, the contribution of single HDAC family members to the differentiation and function of peripheral CD8 + T cells remains elusive. We here demonstrate that HDAC7-deficiency leads to the upregulation of immune c...

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Identifiers and source

Literature Corpus work: ab084806-e008-5363-858e-aecd62ae1aaa
DOI: 10.1101/2022.09.18.508452

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